Description

N(4),N(4)-Dimethyl-5-Azacytidine is a chemically modified nucleoside analog, specifically a dimethylated derivative of the well-known epigenetic modulator 5-azacytidine. This modification enhances its stability and alters its biological activity profile, making it a valuable research-grade compound for advanced biochemical and pharmacological studies. It is primarily utilized by research institutions and pharmaceutical developers focused on oncology, epigenetics, and nucleoside chemistry.

Application

• Epigenetic Research: Serves as a tool compound for studying DNA methylation dynamics and gene expression regulation in cellular models.
• Oncology R&D: Investigated for its potential cytotoxic and differentiation-inducing effects on various cancer cell lines.
• Biochemical Synthesis: Used as a specialized building block or intermediate in the synthesis of novel nucleoside-based pharmaceuticals.
• Enzyme Inhibition Studies: Acts as a potential inhibitor for enzymes involved in nucleotide metabolism, such as cytidine deaminase.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	N(4),N(4)-Dimethyl-5-Azacytidine
CAS No.	27826-77-3
Molecular Formula	C9H15N5O5
Molecular Weight	273.25 g/mol
Synonyms	4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, N(4),N(4)-Dimethyl; 5-Azacytidine, N(4),N(4)-dimethyl-; 1-(β-D-Ribofuranosyl)-4-(dimethylamino)-1,3,5-triazin-2(1H)-one; 4-(Dimethylamino)-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; N(4),N(4)-Dimethyl-4-amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; Dimethylazacytidine
EINECS	Contact for details

Quality Control

Our N(4),N(4)-Dimethyl-5-Azacytidine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.