Description

5-Propyl-2'-Deoxyuridine is a modified nucleoside analog, a key building block in medicinal chemistry and biochemical research. This compound is valued for its role in the synthesis of novel antiviral and anticancer agents, where structural modifications can significantly alter biological activity and selectivity. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on nucleoside-based therapeutics and molecular probes.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel antiviral and antineoplastic (anticancer) nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate DNA/RNA metabolism and repair mechanisms.
• Pro-drug Development: Serves as a modified scaffold for developing targeted pro-drugs with enhanced cellular uptake and reduced side effects.
• Antisense Oligonucleotide Synthesis: Incorporated into oligonucleotide sequences to modulate binding affinity, stability, and specificity.
• Molecular Biology Tool: Employed in studying DNA replication, mutagenesis, and the function of viral polymerases (e.g., Herpesvirus, Hepatitis B).
• Labeled Compound Synthesis: Acts as a starting material for preparing isotopically labeled (e.g., 13C, 15N, 3H) nucleosides for metabolic tracing and pharmacokinetic studies.

Basic Information

Product Name	5-Propyl-2'-Deoxyuridine
CAS No.	27826-74-0
Molecular Formula	C12H18N2O5
Molecular Weight	270.28 g/mol
Synonyms	5-Propyl-2'-deoxyuridine; 5-Propyldeoxyuridine; 2'-Deoxy-5-propyluridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-propylpyrimidine-2,4-dione; 5-n-Propyl-2'-deoxyuridine; dP-Urd; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 5-Propyl-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.