Description

Hexahydro-1H-Azepine-1-Carbonyl Chloride is a versatile and highly reactive organic intermediate, specifically an acyl chloride derivative of hexamethyleneimine. This compound is crucial for introducing the azepane (hexamethyleneimine) moiety into more complex molecular structures via amide bond formation. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), fine chemicals, and novel compounds requiring this specific saturated seven-membered nitrogen heterocycle.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates and active pharmaceutical ingredients (APIs) containing the azepane ring system, which is found in various therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of herbicides, fungicides, and insecticides where the azepane structure imparts desired biological activity.
• Polymer Chemistry: Serves as a monomer or modifying agent in the production of specialty polymers, including polyamides and coatings.
• Chemical Research & Development: An essential reagent in organic synthesis for constructing complex molecules, particularly in medicinal chemistry for structure-activity relationship (SAR) studies.
• Ligand and Catalyst Preparation: Used to synthesize novel ligands and organocatalysts for asymmetric synthesis and other catalytic processes.
• Material Science: Employed in the surface modification of materials and the creation of advanced functional materials with specific chemical properties.

Basic Information

Product Name	Hexahydro-1H-Azepine-1-Carbonyl Chloride
CAS No.	27817-35-2
Molecular Formula	C7H12ClNO
Molecular Weight	161.63 g/mol
Synonyms	1-Azepanecarbonyl Chloride; Hexamethyleneimine-1-carbonyl Chloride; Perhydroazepine-1-carbonyl Chloride; 1-(Chlorocarbonyl)azepane; Azepane-1-carbonyl chloride; Heptamethyleneimine-1-carbonyl Chloride; Homopiperidine-1-carbonyl Chloride
EINECS	Contact for details

Quality Control

Our Hexahydro-1H-Azepine-1-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and highly volatile nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C for long-term stability. Keep away from moisture, heat, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.15 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.