Description

(S)-2-Methylbutanoyl Chloride is a chiral, enantiomerically pure acid chloride derivative of 2-methylbutanoic acid. This high-purity intermediate is critical for introducing the (S)-2-methylbutanoyl moiety into target molecules with precise stereochemical control. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of active pharmaceutical ingredients (APIs), chiral ligands, and other specialty chemicals. Its reactivity makes it a valuable building block for amide and ester formation under mild conditions.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure Active Pharmaceutical Ingredients (APIs) and prodrugs.
• Agrochemical Synthesis: Used in the production of chiral pesticides, herbicides, and fungicides where specific stereochemistry enhances biological activity.
• Chiral Ligand & Catalyst Preparation: Serves as a precursor for synthesizing sophisticated chiral auxiliaries, ligands for asymmetric catalysis, and resolving agents.
• Peptide & Protein Research: Employed for the acylation of amino groups in peptides or for modifying biomolecules to study structure-activity relationships.
• Flavor & Fragrance Industry: Intermediate in the synthesis of specific, high-value ester compounds used in premium flavor and fragrance formulations.
• Material Science: Monomer or modifying agent for creating polymers with specific chiral centers or functional groups for advanced material properties.
• Organic Synthesis Research: Versatile reagent in academic and industrial R&D for exploring new synthetic methodologies involving acyl chloride chemistry.

Basic Information

Product Name	(S)-2-Methylbutanoyl Chloride
CAS No.	27763-54-8
Molecular Formula	C5H9ClO
Molecular Weight	120.58 g/mol
Synonyms	(S)-2-Methylbutyryl chloride; (S)-2-Methylbutanoic acid chloride; L-2-Methylbutanoyl chloride; (S)-(-)-2-Methylbutyryl chloride; (2S)-2-Methylbutanoyl chloride; (S)-2-Methylbutyroyl chloride; (S)-Active amyl chloride; (S)-Sec-butylcarbonyl chloride
EINECS	Contact for details

Quality Control

Our (S)-2-Methylbutanoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting standards for enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, assay, impurity profile, and specific rotation are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C under an inert atmosphere (e.g., nitrogen or argon). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed and handled under dry conditions to prevent hydrolysis. Keep away from strong bases, oxidizers, and alcohols.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]D20	-15° to -18° (c=1, in CHCl3)
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.