Description

2,2,2-Trifluoroethyl Chloroformate is a highly reactive and versatile fluorinated chloroformate ester, a key building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 2,2,2-trifluoroethoxycarbonyl (Troc) protecting group, which is crucial for the selective protection of amines and alcohols in complex molecule assembly. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries, where it enables the synthesis of sophisticated intermediates and active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate Synthesis: As a key reagent for introducing the Troc protecting group in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for peptides and complex heterocycles.
• Agrochemical Manufacturing: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoroethyl moiety can enhance biological activity and environmental stability.
• Peptide Chemistry: Employed for the temporary protection of amino groups during solid-phase and solution-phase peptide synthesis, allowing for orthogonal deprotection strategies.
• Material Science: Serves as a monomer or modifying agent in the synthesis of fluorinated polymers and specialty materials with unique surface properties and chemical resistance.
• Cross-Coupling Reagent: Acts as an activating agent for carboxylic acids, facilitating the formation of anhydrides or mixed carbonates for subsequent nucleophilic substitution reactions.
• Derivatization Agent: Used in analytical chemistry to derivative amines and alcohols for improved detection and separation in chromatographic techniques like GC and HPLC.

Basic Information

Product Name	2,2,2-Trifluoroethyl Chloroformate
CAS No.	27746-99-2
Molecular Formula	C3H2ClF3O2
Molecular Weight	162.50 g/mol
Synonyms	Chloroformic Acid 2,2,2-Trifluoroethyl Ester; 2,2,2-Trifluoroethyl Carbonochloridate; Trifluoroethyl Chloroformate; Troc-Cl; 2,2,2-Trifluoroethoxycarbonyl Chloride; (2,2,2-Trifluoroethoxy)carbonyl Chloride; Carbonochloridic Acid 2,2,2-Trifluoroethyl Ester
EINECS	Contact for details

Quality Control

Every batch of 2,2,2-Trifluoroethyl Chloroformate is produced and tested under strict quality management systems to ensure consistency and reliability for your critical syntheses. Our standard grade typically meets a purity specification of ≥98% (by GC or HPLC), with stringent controls for key impurities. A comprehensive Certificate of Analysis (COA) detailing assay, identity (IR, NMR), and impurity profile is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and moisture-sensitive (hygroscopic) nature, this product should be stored in a cool, dry, and well-ventilated place, ideally at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.5%
Density (at 20°C)	~1.50 g/mL
Refractive Index (n20D)	~1.355

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.