Description

6-Thioinosine-5'-Triphosphate is a chemically modified nucleotide analog where the oxygen atom at the 6-position of the purine ring is replaced by sulfur. This modification is critical for its role as a substrate analog in enzymatic studies and as a tool in biochemical research. It is primarily utilized by researchers in molecular biology, enzymology, and medicinal chemistry for investigating nucleotide-dependent processes, enzyme mechanisms, and as a potential precursor for novel therapeutic agents. The compound is supplied with a high level of purity to ensure reliable and reproducible experimental results.

Application

• Enzymology Research: Used as a substrate or inhibitor to study the kinetics and mechanisms of ATP-dependent enzymes, such as kinases and polymerases.
• Molecular Biology: Serves as a modified nucleotide for in vitro transcription/translation studies or to probe nucleic acid-protein interactions.
• Medicinal Chemistry: Investigated as a precursor or active component in the development of antiviral or anticancer nucleotide analogs.
• Biochemical Assay Development: Employed in the design and validation of high-throughput screening assays for drug discovery.
• Metabolic Pathway Analysis: Acts as a tracer or analog to study purine and nucleotide salvage pathways in cellular systems.
• Structural Biology: Utilized in X-ray crystallography or NMR studies to determine enzyme-ligand complex structures.

Basic Information

Product Name	6-Thioinosine-5'-Triphosphate
CAS No.	27652-34-2
Molecular Formula	C10H16N4O13P3S
Molecular Weight	541.22 g/mol
Synonyms	6-Thio-ITP; 6-Thioinosine triphosphate; 6-Mercaptoinosine 5'-triphosphate; 6-Thio-ITP sodium salt; ITP-6-thiol; 6-SH-ITP; Inosine 5'-(tetrahydrogen triphosphate), 6-thio-; 6-Thioinosine-5'-(tetrahydrogen triphosphate)
EINECS	Contact for details

Quality Control

Our 6-Thioinosine-5'-Triphosphate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated under an inert atmosphere. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water or suitable aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.