Description

2,2-Dimethylpropionyl Bromide is a versatile acyl bromide derivative, specifically the brominated form of pivalic acid, serving as a crucial building block in advanced organic synthesis. Its primary value lies in its high reactivity as an acylating agent, enabling the efficient introduction of the sterically hindered pivaloyl group into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to create active ingredients, advanced intermediates, and functional materials.

Application

• Pharmaceutical intermediate for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the pivaloyl protecting group.
• Key reagent in peptide coupling and acylation reactions to modify molecular structures.
• Building block for the production of agrochemicals, such as herbicides and fungicides.
• Intermediate in the synthesis of specialty polymers and advanced materials.
• Used in organic research and development for creating novel compounds with specific steric properties.
• Starting material for the preparation of other pivalic acid derivatives and fine chemicals.

Basic Information

Product Name	2,2-Dimethylpropionyl Bromide
CAS No.	27644-18-4
Molecular Formula	C5H9BrO
Molecular Weight	165.03 g/mol
Synonyms	Pivaloyl Bromide; Trimethylacetyl Bromide; 2,2-Dimethylpropanoyl Bromide; Neopentanoyl Bromide; Pivalic Acid Bromide; Bromopivaloyl; NSC 71968
EINECS	248-577-5

Quality Control

Our 2,2-Dimethylpropionyl Bromide is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including assay, identity confirmation, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.