Description

Cytidylyl(3'-5')Guanosine Ammonium is a high-purity dinucleoside monophosphate salt, a critical building block in nucleic acid chemistry. This compound is essential for research and development in oligonucleotide synthesis, serving as a key intermediate for creating specific RNA sequences and analogs. It is primarily utilized by biopharmaceutical companies, academic research institutions, and CROs focused on mRNA therapeutics, antisense technology, and molecular biology applications.

Application

• Oligonucleotide Synthesis: As a protected phosphoramidite precursor or solid-phase synthesis intermediate for constructing custom RNA strands.
• mRNA Therapeutic Research: For the development and scale-up of modified mRNA vaccines and therapies, where precise sequence control is paramount.
• Biochemical Research: As a substrate or standard in enzymatic studies involving RNA polymerases, ligases, and nucleases.
• Antisense & siRNA Development: A fundamental component in the synthesis of short interfering RNA (siRNA) and antisense oligonucleotides for gene silencing studies.
• Diagnostic Probe Manufacturing: Used in the production of labeled probes for techniques like FISH (Fluorescence In Situ Hybridization) and PCR.
• Reference Standard: Serves as a high-purity analytical standard for quality control in nucleic acid manufacturing and research.

Basic Information

Product Name	Cytidylyl(3'-5')Guanosine Ammonium
CAS No.	27553-01-1
Molecular Formula	C19H28N9O12P
Molecular Weight	581.46 g/mol
Synonyms	3'-5'-Cytidylylguanosine Ammonium Salt; CpG Ammonium Salt; Cytidylyl(3'→5')guanosine ammonium; Cytidylyl-guanosine ammonium; 5'-O-[Hydroxy([(2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-yl]oxy)phosphoryl]cytidine ammonium salt; Ammonium Cytidylyl(3'-5')Guanosine; CpG dinucleotide ammonium salt
EINECS	Contact for details

Quality Control

Our Cytidylyl(3'-5')Guanosine Ammonium is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Ammonium Content	Conforms to theoretical
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.