Description

Levobupivacaine Hydrochloride is the pure S(-)-enantiomer of bupivacaine hydrochloride, a long-acting amide-type local anesthetic agent. Its primary value lies in its enhanced safety profile and reduced cardiotoxicity compared to the racemic mixture, making it a critical active pharmaceutical ingredient (API) for advanced anesthetic formulations. This high-purity compound is essential for manufacturers in the pharmaceutical industry developing injectable solutions for surgical anesthesia, epidural blocks, and postoperative pain management.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable solutions for local and regional anesthesia.
• Surgical Anesthesia: Formulated for nerve blocks, epidural anesthesia, and spinal anesthesia in various surgical procedures.
• Pain Management: Used in solutions for postoperative pain relief and labor analgesia.
• Research & Development: Serves as a key reference standard and starting material for pharmacological studies and new drug development.
• Veterinary Medicine: Applicable in veterinary surgical and diagnostic procedures requiring local anesthesia.

Basic Information

Product Name	Levobupivacaine Hydrochloride
CAS No.	27262-48-2
Molecular Formula	C18H28N2O·HCl
Molecular Weight	324.89 g/mol
Synonyms	(S)-(-)-Bupivacaine Hydrochloride; Levobupivacaine HCl; Chirocaine® (brand name); (2S)-1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride; (-)-Bupivacaine Hydrochloride; S-Bupivacaine Hydrochloride; L-Bupivacaine Hydrochloride
EINECS	Contact for details

Quality Control

Our Levobupivacaine Hydrochloride is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Each batch undergoes comprehensive analytical testing including chiral purity verification, assay, and impurity profiling to ensure it meets the stringent requirements for pharmaceutical actives. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.