Description

Levobupivacaine is the pure S(-)-enantiomer of bupivacaine, a long-acting amide-type local anesthetic. This specific stereoisomer offers a potentially improved safety profile regarding cardiotoxicity compared to the racemic mixture, making it a critical active pharmaceutical ingredient (API) for advanced anesthetic formulations. It is essential for pharmaceutical manufacturers developing regional anesthesia and postoperative pain management solutions. The product is supplied under the identifier CAS NO 27262-47-1.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable local anesthetic solutions for surgical and medical procedures.
• Regional Anesthesia: Formulation into products for nerve blocks, epidural anesthesia, and spinal anesthesia.
• Postoperative Analgesia: Used in continuous infusion pumps or extended-release formulations for prolonged pain relief after surgery.
• Obstetric Analgesia: Key component in epidural solutions for pain management during labor and delivery.
• Veterinary Medicine: Application in anesthetic and analgesic protocols for animals in veterinary surgery.
• Research & Development: Serves as a reference standard and building block in pharmacological research and the development of new anesthetic agents.

Basic Information

Product Name	Levobupivacaine
CAS No.	27262-47-1
Molecular Formula	C18H28N2O
Molecular Weight	288.43 g/mol
Synonyms	(S)-(-)-Bupivacaine; Levobupivacaine Hydrochloride (salt form); Chirocaine®; (2S)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide; (-)-1-Butyl-2',6'-pipecoloxylidide; S-Bupivacaine; Left-handed bupivacaine
EINECS	Contact for details

Quality Control

Our Levobupivacaine is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols are designed to ensure high purity, correct stereochemistry, and consistency across batches. Certificates of Analysis (COA) detailing specifications such as enantiomeric purity, assay, and impurity profiles are provided with each shipment to support your regulatory and formulation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packing.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (S-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.