Description

(R)-(+)-Bupivacaine Monohydrochloride is the pure enantiomeric salt form of the widely used long-acting local anesthetic agent. This high-purity chiral compound is critical for pharmaceutical research and development, particularly in studies requiring stereochemical specificity. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on developing advanced anesthetic formulations and investigating receptor-specific pharmacological effects.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of enantiomerically pure local anesthetic formulations.
• Analytical Reference Standard: Used in HPLC, GC, and other chromatographic methods for quality control and assay development.
• Pharmacological Research: Essential for stereoselective studies of sodium channel blockade, duration of action, and toxicity profiles.
• Process Development & Validation: Serves as a critical standard in developing and validating chiral synthesis and purification processes.
• Clinical Trial Material: Used in the preparation of investigational medicinal products for clinical studies.
• Academic & Institutional Research: Employed in universities and research labs for neuroscience and anesthesiology studies.

Basic Information

Product Name	(R)-(+)-Bupivacaine Monohydrochloride
CAS No.	27262-46-0
Molecular Formula	C18H28N2O • HCl
Molecular Weight	324.89 g/mol
Synonyms	(R)-(+)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride; (R)-Bupivacaine hydrochloride; Dexbupivacaine hydrochloride; (R)-1-Butyl-2',6'-pipecoloxylidide hydrochloride; Levobupivacaine isomer hydrochloride; (2R)-1-Butyl-2-(2,6-dimethylanilino)piperidine-1-ium chloride
EINECS	Contact for details

Quality Control

Our (R)-(+)-Bupivacaine Monohydrochloride is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing including chiral purity by HPLC, identity confirmation by IR and NMR, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP and relevant pharmacopeial guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.