Description

(R)-(+)-Bupivacaine Hcl CAS NO 27262-45-9 is the hydrochloride salt of the pharmacologically active (R)-(+)-enantiomer of bupivacaine, a long-acting amide-type local anesthetic. This high-purity chiral intermediate is critical for research and development in advanced pharmaceutical formulations, particularly for producing enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on developing novel anesthetic and analgesic drugs with improved safety and efficacy profiles.

Application

• Pharmaceutical API Synthesis: As a key chiral building block for the manufacture of enantiomerically pure (R)-(+)-bupivacaine hydrochloride as an active pharmaceutical ingredient.
• Analgesic & Anesthetic Research: For preclinical and clinical research into long-duration local anesthetics and pain management solutions.
• Chiral Chemistry Studies: Serving as a reference standard and starting material in stereochemistry research and asymmetric synthesis development.
• Formulation Development: Used in the development of controlled-release, injectable, and topical formulations requiring the specific (R)-(+)-enantiomer.
• Pharmacology & Toxicology: As a standard compound for studying the pharmacokinetics, pharmacodynamics, and safety profile of specific bupivacaine enantiomers.
• Quality Control & Regulatory Compliance: Employed as an analytical reference standard for HPLC, GC, or spectroscopic methods to ensure product quality and meet regulatory filing requirements.

Basic Information

Product Name	(R)-(+)-Bupivacaine Hydrochloride
CAS No.	27262-45-9
Molecular Formula	C₁₈H₂₈N₂O • HCl
Molecular Weight	324.89 g/mol
Synonyms	(R)-(+)-Bupivacaine Hydrochloride; (R)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride; Levobupivacaine Hydrochloride (Note: Verify isomer); (R)-Bupivacaine HCl; (+)-Bupivacaine Hydrochloride; Bupivacaine (R)-enantiomer hydrochloride; Bupivacaine Hydrochloride (R)-(+) form; Dexbupivacaine Hydrochloride (Note: Verify isomer)
EINECS	Contact for details

Quality Control

Our (R)-(+)-Bupivacaine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, identification, and impurity profiling via HPLC and other pharmacopeial methods, to ensure it meets stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.