Description

2'-Deoxy-5-Fluorouridine 5'-Methanesulfonate 3'-Acetate is a key fluorinated nucleoside derivative, serving as a critical protected intermediate in the synthesis of advanced pharmaceutical compounds. Its primary value lies in enabling precise chemical modifications for the development of targeted therapeutics, particularly in oncology. This high-purity intermediate is essential for research institutions and pharmaceutical manufacturers focused on developing novel antiviral and anticancer agents, where reliable quality and supply chain integrity are paramount.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of fluoropyrimidine-based anticancer drugs, such as Capecitabine and related prodrugs.
• Antiviral Drug Research: Used in the research and development of nucleoside analogue antiviral agents targeting viral polymerases.
• Biochemical Research: Serves as a modified nucleoside precursor in studies involving DNA/RNA synthesis inhibition and mechanism of action investigations.
• Process Chemistry & Scale-Up: Employed in process development and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for the custom synthesis of more complex, labeled, or structurally unique nucleoside derivatives for specialized research programs.

Basic Information

Item	Details
Product Name	2'-Deoxy-5-Fluorouridine 5'-Methanesulfonate 3'-Acetate
CAS No.	27095-26-7
Molecular Formula	C13H17FN2O8S
Molecular Weight	380.35 g/mol
Synonyms	5'-O-Methanesulfonyl-3'-O-acetyl-5-fluoro-2'-deoxyuridine; 3'-Acetyl-5'-O-methanesulfonyl-5-fluoro-2'-deoxyuridine; 5-Fluoro-2'-deoxyuridine 5'-methanesulfonate 3'-acetate; 5-FdUrd 5'-mesylate 3'-acetate; 5-FUDR 5'-mesylate 3'-acetate; 5-Fluorodeoxyuridine 5'-methanesulfonate 3'-acetate; Protected 5-Fluorodeoxyuridine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5-Fluorouridine 5'-Methanesulfonate 3'-Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical synthesis. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each batch to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.