Description

Decarbamoylmethylmitomycin A is a key synthetic intermediate and derivative of the potent mitomycin family of antitumor antibiotics. This compound is of significant interest in pharmaceutical research and development for the synthesis of novel chemotherapeutic agents and biochemical probes. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug discovery and advanced synthetic chemistry.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel mitomycin analogs and prodrugs for cancer therapy research.
• Biochemical Research: Used as a reference standard and tool compound in studies of DNA alkylation, cross-linking mechanisms, and bioreductive activation.
• Antitumor Agent Development: Serves as a core structure for modifying the mitomycin pharmacophore to improve efficacy, reduce toxicity, or overcome drug resistance.
• Academic Research: Employed in university and institutional labs for investigating the structure-activity relationships (SAR) of anticancer compounds.
• Process Chemistry: Used in scale-up and optimization studies for the manufacturing routes of complex pharmaceutical active ingredients (APIs).

Basic Information

Product Name	Decarbamoylmethylmitomycin A
CAS No.	26909-45-5
Molecular Formula	C16H19N3O5
Molecular Weight	333.34 g/mol
Synonyms	7-(Aminomethyl)mitosane; Decarbamoylmitomycin A; Mitomycin A derivative; 1,2-trans-1-Hydroxy-2,7-diaminomitosane; 7-Aminomethyl-1α,2β-dihydroxymitosane; (1R,2S,6S,7S,8S)-8-Aminomethyl-6-methoxy-2,7-dimethyl-1,2,6,7,8,8a-hexahydro-1,4-dioxopyrrolo[1,2-a]indol-5-ol; 7-(Aminomethyl)-1α,2β-dihydroxy-6-methoxy-2,7-dimethylmitosane
EINECS	Contact for details

Quality Control

Our Decarbamoylmethylmitomycin A is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and compliance needs in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to brownish powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Related Substances (HPLC)	Total impurities ≤5.0%
Single Unknown Impurity	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.