Description

3',5'-Di-o-Acetyl-2'-Azido-2'-Deoxyuridine is a key nucleoside analog derivative, specifically a modified uridine compound. This chemical is a critical synthetic intermediate in the development of novel antiviral and anticancer pharmaceuticals, particularly in the synthesis of chain-terminating nucleoside reverse transcriptase inhibitors. It is essential for research and production in pharmaceutical development, biotechnology, and advanced organic synthesis, where precise molecular modification is required.

Application

• Pharmaceutical Intermediate: A vital building block for the synthesis of antiviral drugs, including potential treatments for HIV and other viral infections.
• Anticancer Agent Research: Used in the development and study of nucleoside-based chemotherapeutic compounds.
• Biochemical Probe Synthesis: Serves as a precursor for creating labeled or modified nucleosides used in molecular biology and diagnostic research.
• Organic Synthesis: A versatile intermediate for introducing azido and acetyl-protected sugar moieties into complex organic molecules.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the efficacy and selectivity of nucleoside drugs.
• Click Chemistry Substrate: The azido functional group makes it suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions in bioconjugation.

Basic Information

Product Name	3',5'-Di-o-Acetyl-2'-Azido-2'-Deoxyuridine
CAS No.	26889-43-0
Molecular Formula	C13H15N5O7
Molecular Weight	353.29 g/mol
Synonyms	2'-Azido-2'-deoxy-3',5'-di-O-acetyluridine; 2'-Azido-3',5'-di-O-acetyl-2'-deoxyuridine; 1-[(2R,3S,5R)-3-Azido-5-(acetyloxymethyl)-2-tetrahydrofuranyl]-2,4(1H,3H)-pyrimidinedione 3',5'-diacetate; 3',5'-Diacetyl-2'-azido-2'-deoxyuridine; AZDU diacetate; 2'-Azido-2'-deoxyuridine 3',5'-diacetate
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Acetyl-2'-Azido-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.