Description

2'-Amino-D-Cytidine is a modified nucleoside derivative of cytidine, featuring an amino group at the 2' position of the sugar moiety. This structural modification is critical for its role as a key building block and intermediate in the synthesis of oligonucleotides and nucleotide analogs. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug discovery, particularly for the development of antisense oligonucleotides, siRNA, and other therapeutic nucleic acids. The compound's high purity and defined structure are essential for ensuring the efficacy and specificity of the final biopharmaceutical products.

Application

• Pharmaceutical Intermediate: A crucial raw material for synthesizing novel nucleotide-based therapeutics, including antisense drugs and siRNA constructs.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies related to nucleic acid metabolism and repair.
• Proteomics & Genomics: Serves as a modified base in the preparation of custom oligonucleotide probes and primers for advanced diagnostic assays.
• Antiviral Drug Development: Investigated as a precursor in the synthesis of nucleoside analogs with potential antiviral activity.
• Labeled Compound Synthesis: Acts as a starting point for introducing radioactive or fluorescent labels into oligonucleotides for tracking and imaging studies.
• Academic Research: Employed in university and institutional labs for fundamental studies on RNA structure, function, and stability.

Basic Information

Product Name	2'-Amino-D-Cytidine
CAS No.	26889-42-9
Molecular Formula	C9H14N4O5
Molecular Weight	258.23 g/mol
Synonyms	2'-Amino-2'-deoxycytidine; 1-(2-Amino-2-deoxy-β-D-ribofuranosyl)cytosine; 2'-Amino-2'-deoxycytidine; D-2'-Aminocytidine; 2'-Amino-cytidine; 2'-Deoxy-2'-aminocytidine; Cytidine, 2'-amino-2'-deoxy-; 2'-NH2-dCyd
EINECS	Contact for details

Quality Control

Every batch of 2'-Amino-D-Cytidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), identity (by IR and NMR), and moisture content. Our quality protocols are designed to support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.