Description

2'-Amino-D-Uridine is a modified nucleoside analog where the 2'-hydroxyl group of the ribose sugar is replaced by an amino group. This structural modification is critical for imparting unique biochemical properties, making it a valuable building block in nucleic acid research and therapeutic development. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on oligonucleotide synthesis, antisense technology, and the development of novel RNA-based therapeutics.

Application

• Oligonucleotide Synthesis: A key monomer for the solid-phase synthesis of modified RNA and DNA strands, enhancing stability and binding affinity.
• Antisense & siRNA Research: Used to create chemically modified oligonucleotides for gene silencing applications, improving nuclease resistance and pharmacokinetic profiles.
• Structural Biology Studies: Incorporated into RNA to study structure-function relationships and the impact of 2'-modifications on duplex stability and conformation.
• Therapeutic Nucleoside Development: Serves as a precursor or intermediate in the synthesis of novel antiviral or anticancer nucleoside analogs.
• Diagnostic Probe Design: Utilized in the creation of high-specificity probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic assays.
• Bioconjugation & Labeling: The 2'-amino group provides a reactive handle for attaching fluorescent dyes, affinity tags, or other functional moieties to oligonucleotides.

Basic Information

Product Name	2'-Amino-D-Uridine
CAS No.	26889-39-4
Molecular Formula	C9H13N3O6
Molecular Weight	259.22 g/mol
Synonyms	2'-Amino-2'-deoxyuridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-(aminomethyl)oxolan-2-yl)pyrimidine-2,4-dione; 2'-Amino-2'-deoxyuridine; 2'-Amino-2'-deoxy-Uridine; 2'-Amino-deoxyuridine; 2'-ADU; 2'-NH2-dU
EINECS	Contact for details

Quality Control

Our 2'-Amino-D-Uridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.