Description

1,7-Dimethylguanosine is a modified nucleoside derivative of guanosine, characterized by methylation at the N1 and N7 positions of the purine ring. This specific modification makes it a valuable biochemical tool and reference standard for research into RNA modification, epigenetic regulation, and cellular metabolism. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical development, and diagnostic sectors.

Application

• Biochemical Research: Used as a critical reference standard and reagent in studies of RNA modifications, tRNA function, and post-transcriptional gene regulation.
• Pharmaceutical Development: Serves as a building block or intermediate in the synthesis of novel nucleoside analogs for potential therapeutic applications.
• Diagnostic Assays: Employed as a calibrant or control in liquid chromatography-mass spectrometry (LC-MS) and other analytical methods for metabolomics and biomarker discovery.
• Enzymology Studies: Acts as a substrate or inhibitor for enzymes involved in nucleotide metabolism and modification, such as methyltransferases.
• Academic Research: Essential for fundamental research in molecular biology, genetics, and epigenetics to understand the role of modified nucleosides.

Basic Information

Product Name	1,7-Dimethylguanosine
CAS No.	26624-46-4
Molecular Formula	C₁₂H₁₇N₅O₅
Molecular Weight	311.29 g/mol
Synonyms	N1,N7-Dimethylguanosine; 1,7-Dimethylguanosine; 1-Methyl-7-methylguanosine; Guanosine, 1,7-dimethyl-; 1,7-Dimethyl-9-β-D-ribofuranosylguanine; N(1),N(7)-Dimethylguanosine
EINECS	Contact for details

Quality Control

Our 1,7-Dimethylguanosine is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals, ensuring reliable performance as a reference material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.