Description

7-Methylguanosine Triphosphate is a chemically modified nucleotide triphosphate analog that plays a crucial role in advanced biochemical research and development. Its primary value lies in its ability to serve as a substrate or inhibitor for various enzymes, including methyltransferases and polymerases, enabling studies on RNA cap structure, epigenetics, and nucleic acid metabolism. This high-purity biochemical is essential for researchers and manufacturers in the fields of pharmaceutical development, molecular diagnostics, and life science research, where precise and reliable reagents are paramount for experimental success.

Application

• RNA Cap Analogue Synthesis: A key substrate for enzymatic and chemical synthesis of mRNA cap structures (m7GpppG and derivatives) for mRNA vaccine and therapeutic research.
• Enzymology Studies: Used as a specific substrate or competitive inhibitor to study the kinetics and mechanism of RNA guanine-N7 methyltransferases and other nucleotide-binding enzymes.
• Epigenetic Research: Employed in investigations of RNA methylation dynamics, its role in gene expression regulation, and its implications in disease pathways.
• Biochemical Assay Development: Serves as a critical component in high-throughput screening (HTS) assays to identify novel modulators of methyltransferase activity for drug discovery.
• Nucleic Acid Labeling & Sequencing: Can be utilized in next-generation sequencing platforms and techniques that require modified nucleotides for tracking or termination.
• Reference Standard: Acts as a high-purity analytical standard for quality control in the production of nucleotide-based APIs or diagnostic kits.

Basic Information

Product Name	7-Methylguanosine Triphosphate
CAS No.	26554-26-7
Molecular Formula	C11H18N5O14P3
Molecular Weight	561.21 g/mol
Synonyms	7-Methyl-GTP; N7-Methylguanosine-5'-triphosphate; m7GTP; 7-Methylguanosine 5'-(tetrahydrogen triphosphate); 5'-Triphosphoric acid, 7-methylguanosine; Guanosine, 7-methyl-, 5'-(tetrahydrogen triphosphate); N(7)-Methylguanosine triphosphate
EINECS	Contact for details

Quality Control

Our 7-Methylguanosine Triphosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the stringent requirements for research and bioproduction. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, potency, and absence of specific impurities like nucleobase contaminants or residual solvents. Our quality commitment aligns with the standards expected for GMP-grade raw materials used in critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere to maintain stability and prevent hydrolysis of the triphosphate moiety. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area Percent)
Assay (UV)	≥ 90% (on anhydrous basis)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.