Description

Benzophenone-4-Isothiocyanate is a bifunctional organic compound that combines a benzophenone photoaffinity label with a reactive isothiocyanate group. This unique structure makes it a valuable intermediate for the synthesis of photoactivatable probes and cross-linking agents used in biochemical research. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications such as protein labeling, affinity chromatography, and the study of biomolecular interactions.

Application

• Photoaffinity Labeling: Acts as a key reagent for covalently tagging proteins, peptides, and other biomolecules upon UV irradiation to study binding sites and interactions.
• Bioconjugation & Probe Synthesis: Serves as a versatile building block for creating fluorescent, affinity, or therapeutic probes by reacting the isothiocyanate group with amines.
• Material Surface Functionalization: Used to modify surfaces (e.g., chips, beads) with photoreactive groups for immobilizing biomolecules in biosensor and microarray development.
• Cross-linking Agent: Enables the study of protein-protein or protein-ligand complexes by forming stable cross-links upon photoactivation.
• Pharmaceutical Research: Employed in drug discovery for target identification and validation through photoaffinity-based strategies.

Basic Information

Product Name	Benzophenone-4-Isothiocyanate
CAS No.	26328-59-6
Molecular Formula	C14H9NO2S
Molecular Weight	255.29 g/mol
Synonyms	4-Isothiocyanatobenzophenone; Benzophenone-4-isothiocyanate; 4-Benzophenone isothiocyanate; p-Isothiocyanatobenzophenone; 4-(Isothiocyanato)benzophenone; NSC 334906; 4-Benzoylphenyl isothiocyanate
EINECS	Contact for details

Quality Control

Our Benzophenone-4-Isothiocyanate is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific research or cGMP requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to moisture, heat, or light should be avoided to maintain stability and reactivity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.