Description

2',3'-Dideoxyadenosine 5'-Phosphate is a chemically modified nucleoside monophosphate analog, a key building block in biochemical research and pharmaceutical development. Its primary value lies in its role as a chain terminator and inhibitor of viral reverse transcriptase, making it a critical intermediate for antiviral drug discovery and nucleotide-based therapeutics. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors, particularly those focused on virology and nucleic acid chemistry.

Application

• Antiviral Research & Development: Serves as a crucial intermediate in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) for HIV and other retroviral therapies.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving DNA/RNA polymerases and reverse transcriptases.
• Nucleotide Analog Synthesis: Acts as a foundational building block for creating modified nucleotides with tailored biological activities.
• Pharmaceutical Intermediates: Employed in the cGMP-compliant manufacturing of active pharmaceutical ingredients (APIs) for antiviral medications.
• Molecular Biology: Utilized in studies of DNA replication mechanisms and the development of diagnostic probes.
• Academic & Contract Research: A standard reagent for universities and CROs investigating nucleotide metabolism and antiviral mechanisms of action.

Basic Information

Product Name	2',3'-Dideoxyadenosine 5'-Phosphate
CAS No.	26315-32-2
Molecular Formula	C10H14N5O5P
Molecular Weight	315.22 g/mol
Synonyms	2',3'-Dideoxyadenosine 5'-monophosphate; ddAMP; 2',3'-ddAMP; 9-[(2R,5S)-5-(Phosphonooxymethyl)oxolan-2-yl]purin-6-amine; Cordycepin 5'-monophosphate analog; Dideoxyadenosine monophosphate; Adenosine, 2',3'-dideoxy-, 5'-(dihydrogen phosphate)
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxyadenosine 5'-Phosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research and pharmaceutical-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.