Description

8-Mercaptoguanosine is a modified nucleoside derivative where a thiol group replaces the hydroxyl group at the 8-position of the guanosine base. This compound is a critical building block and research tool in the fields of nucleic acid chemistry and biochemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for applications ranging from oligonucleotide synthesis to biochemical studies. Its unique reactivity makes it valuable for probing nucleic acid structure and function, as well as for developing novel therapeutic agents.

Application

• Oligonucleotide Synthesis: A key monomer for introducing thiol modifications into DNA or RNA strands for labeling, cross-linking, or structural studies.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving purine metabolism and nucleoside-processing enzymes.
• Pharmaceutical Intermediates: Serves as a precursor in the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.
• Probe Development: Enables the creation of fluorescent or affinity-labeled nucleosides for detecting specific nucleic acid sequences or protein interactions.
• Material Science: Investigated for use in creating functionalized surfaces or nanomaterials via thiol-gold chemistry.
• Diagnostic Assay Development: Can be incorporated into probes for sensitive detection systems.

Basic Information

Product Name	8-Mercaptoguanosine
CAS No.	26001-38-7
Molecular Formula	C10H13N5O5S
Molecular Weight	315.31 g/mol
Synonyms	8-Thioguanosine; Guanosine, 8-mercapto-; 8-SH-Guo; 8-Thio-guanosine; 8-Mercapto-guanosine; 8-Sulfhydrylguanosine; 26001-38-7; NSC 177544
EINECS	Contact for details

Quality Control

Our 8-Mercaptoguanosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We can support development projects requiring material compliant with cGMP guidelines for pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The product is light-sensitive and easily oxidized; allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.