Description

Diethyl (4-Chloromethyl)Benzylphosphonate, 95 % is a versatile organophosphorus compound that serves as a key synthetic intermediate in advanced organic synthesis. Its value lies in its bifunctional reactivity, featuring both a phosphonate ester group and a reactive chloromethyl moiety, enabling its use in the construction of complex molecular architectures. This high-purity grade is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable building blocks for drug discovery and material science applications.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of biologically active molecules, including potential drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that require specific phosphonate functionalities.
• Ligand and Catalyst Precursor: Serves as a starting material for the preparation of specialized phosphonate-based ligands used in metal-catalyzed reactions.
• Material Science Research: Employed in the development of novel polymers, flame retardants, and metal-organic frameworks (MOFs) due to its ability to introduce phosphonate groups.
• Cross-Coupling Reactions: Acts as a reagent in Horner-Wadsworth-Emmons (HWE) olefination reactions to form carbon-carbon double bonds with high stereoselectivity.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and molecular tools for studying enzymatic processes.

Basic Information

Product Name	Diethyl (4-Chloromethyl)Benzylphosphonate, 95 %
CAS No.	25596-72-9
Molecular Formula	C12H18ClO3P
Molecular Weight	276.70 g/mol
Synonyms	Diethyl [(4-Chloromethyl)phenyl]methylphosphonate; Diethyl (p-Chloromethyl)benzylphosphonate; Benzylphosphonic acid, (4-chloromethyl)-, diethyl ester; (4-Chloromethyl)benzylphosphonic Acid Diethyl Ester; Diethyl (4-Chlorobenzyl)phosphonate (common misnomer); Phosphonic acid, P-[(4-chloromethyl)phenyl]methyl-, diethyl ester
EINECS	Contact for details

Quality Control

Our Diethyl (4-Chloromethyl)Benzylphosphonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0 %
Water Content (KF)	≤ 0.5 %
Related Substances (HPLC)	Individual impurity ≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.