Description

3'-Fluoro-3'-Deoxythymidine Monophosphate is a chemically modified nucleoside monophosphate analog, a key building block in medicinal chemistry and biochemical research. This compound is valued for its role as a precursor in the synthesis of modified oligonucleotides and as a potential antiviral or anticancer agent probe. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in nucleotide-based drug discovery and molecular biology studies.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel nucleoside analog prodrugs and antiviral agents.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite building block for incorporating fluorine-substituted thymidine into DNA/RNA strands for antisense or siRNA applications.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to investigate polymerase activity and nucleotide metabolism pathways.
• Antiviral Probe Development: Investigated for its potential activity against viral polymerases (e.g., HIV reverse transcriptase, Hepatitis B virus polymerase).
• Labeled Compound Synthesis: Acts as a starting material for the preparation of radiolabeled (e.g., tritium, carbon-14) or fluorescently tagged nucleotides for tracing and imaging studies.
• Medicinal Chemistry SAR Studies: Employed to study the structure-activity relationship (SAR) of fluorinated nucleosides to optimize potency and metabolic stability.

Basic Information

Product Name	3'-Fluoro-3'-Deoxythymidine Monophosphate
CAS No.	25520-83-6
Molecular Formula	C10H14FN2O8P
Molecular Weight	340.20 g/mol
Synonyms	3'-F-3'-dTMP; 3'-Fluoro-3'-deoxythymidine 5'-monophosphate; 1-[(2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 5'-(dihydrogen phosphate); 5'-TMP-3'-F; 3'-Fluoro-5'-TMP; 2'-Deoxy-3'-fluorothymidine 5'-monophosphate; FdTMP; FLT Monophosphate
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-3'-Deoxythymidine Monophosphate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.