Description

5-o-Triphenylmethyl-2-Deoxy-2,3-Didehyrothymidine is a high-purity, protected nucleoside derivative, a critical intermediate in advanced organic synthesis. Its primary value lies in enabling the precise construction of modified oligonucleotides and nucleoside analogs, where protecting group chemistry is essential. This compound is specifically needed by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer drugs, and novel therapeutic nucleic acids. Its role is pivotal in synthetic pathways requiring selective deprotection strategies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase or solution-phase synthesis of modified DNA/RNA strands.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Bioconjugation: Acts as a precursor for labeling nucleotides with probes, tags, or other functional molecules.
• Academic & Industrial R&D: Fundamental reagent for exploring new synthetic methodologies in carbohydrate and heterocyclic chemistry.
• Process Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) in GMP environments.

Basic Information

Product Name	5-o-Triphenylmethyl-2-Deoxy-2,3-Didehyrothymidine
CAS No.	25442-42-6
Molecular Formula	C31H28N2O5
Molecular Weight	508.57 g/mol
Synonyms	5'-O-Tritylthymidine 2',3'-Didehydro-2',3'-dideoxy; 5'-O-(Triphenylmethyl)-2',3'-didehydro-2',3'-dideoxythymidine; 5'-O-Trityl-d4T; 5'-O-Trityl-2',3'-didehydro-2',3'-dideoxythymidine; Stavudine 5'-O-trityl ether; d4T 5'-O-Trityl; NSC 684681; 2',3'-Didehydro-2',3'-dideoxy-5'-O-tritylthymidine
EINECS	Contact for details

Quality Control

Our 5-o-Triphenylmethyl-2-Deoxy-2,3-Didehyrothymidine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. We adhere to ISO 9001 quality management standards, and our analytical methods include HPLC, NMR, and mass spectrometry for definitive characterization. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.