Description

9-(2,5-o-Phosphinico-D-Arabinofuranosyl)-9H-Purin-6-Amine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. Its unique structure, featuring a phosphinico group on the arabinofuranosyl moiety, makes it a valuable intermediate for synthesizing novel therapeutic agents and diagnostic probes. This compound is primarily utilized by research institutions and pharmaceutical companies focused on antiviral drug discovery, oncology research, and the development of nucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Antiviral Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Drug Discovery: Serves as a precursor for creating purine-based compounds that modulate cellular pathways in cancer cells.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism.
• Diagnostic Probe Development: Utilized in the design of labeled nucleotides for molecular diagnostics and imaging.
• Process Chemistry: Acts as a critical intermediate in the scale-up and optimization of synthetic routes for nucleotide drugs.

Basic Information

Product Name	9-(2,5-o-Phosphinico-D-Arabinofuranosyl)-9H-Purin-6-Amine
CAS No.	25406-55-7
Molecular Formula	C10H14N5O7P
Molecular Weight	347.22 g/mol
Synonyms	9-(2,5-Di-O-phosphono-β-D-arabinofuranosyl)adenine; 9-(2,5-Diphosphonoarabinofuranosyl)adenine; 2',5'-Diphosphonoadenosine arabinoside; Adenine Arabinoside 2',5'-Diphosphonate; Ara-A 2',5'-Diphosphonate; Vidarabine 2',5'-Diphosphonate Analog; 9-β-D-Arabinofuranosyladenine 2',5'-bis(dihydrogen phosphate)
EINECS	Contact for details

Quality Control

Our 9-(2,5-o-Phosphinico-D-Arabinofuranosyl)-9H-Purin-6-Amine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.