Description

5'-Amino-5'-Deoxythymidine is a chemically modified nucleoside derivative, serving as a critical building block in oligonucleotide synthesis and pharmaceutical research. Its primary value lies in its role as a versatile intermediate for creating modified DNA/RNA sequences, enabling advanced studies in molecular biology, antisense technology, and drug discovery. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic reagent industries who require reliable, high-quality raw materials for their development pipelines.

Application

• Oligonucleotide Synthesis: A key monomer for the solid-phase synthesis of modified antisense oligonucleotides and aptamers.
• Pharmaceutical Intermediates: Serves as a crucial building block in the development of novel nucleoside-based antiviral and anticancer therapeutics.
• Biochemical Research: Used in studies investigating DNA replication, repair mechanisms, and enzyme-substrate interactions.
• Probe Development: Incorporated into labeled DNA probes for diagnostic assays and genomic research applications.
• Cross-linking Studies: Utilized to introduce amino-functionalized sites into DNA strands for conjugation with reporter molecules or solid supports.

Basic Information

Product Name	5'-Amino-5'-Deoxythymidine
CAS No.	25152-20-9
Molecular Formula	C10H15N3O4
Molecular Weight	241.25 g/mol
Synonyms	5'-Amino-5'-deoxythymidine; 5'-Amino-2'-deoxythymidine; 1-[(2R,4S,5R)-4-Amino-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 5'-Amino-2'-deoxy-5-methyluridine; 5'-Amino-dT; Amino-modified thymidine; 5'-NH2-dT
EINECS	Contact for details

Quality Control

Our 5'-Amino-5'-Deoxythymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the high standards required for research and pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.