Description

Sincalide CAS NO 25126-32-3 is a synthetic C-terminal octapeptide of cholecystokinin (CCK-8), functioning as a potent diagnostic and research agent. Its primary value lies in its ability to stimulate gallbladder contraction and pancreatic secretion, making it a critical tool in medical diagnostics. This product is essential for pharmaceutical manufacturers, clinical diagnostic laboratories, and research institutions focused on gastroenterology and peptide science.

Application

• Diagnostic Imaging: Used in cholescintigraphy (HIDA scans) to assess gallbladder ejection fraction and diagnose biliary dyskinesia or chronic acalculous cholecystitis.
• Pancreatic Function Testing: Employed to stimulate pancreatic secretion for evaluating exocrine pancreatic function in conditions like chronic pancreatitis.
• Pharmaceutical Intermediates: Serves as a key active pharmaceutical ingredient (API) or intermediate in the formulation of diagnostic kits and injectable solutions.
• Biomedical Research: A vital tool in pharmacological studies to investigate CCK receptor binding, signal transduction pathways, and the physiology of the gastrointestinal system.
• Reference Standard: Used as a high-purity calibrant or reference standard in analytical laboratories for quality control of related pharmaceutical products.

Basic Information

Product Name	Sincalide
CAS No.	25126-32-3
Molecular Formula	C₄₉H₆₂N₁₀O₁₆S₂
Molecular Weight	1143.2 g/mol
Synonyms	CCK-8; Cholecystokinin Octapeptide; Sincalide Acetate; Kinevac; SQ 19,844; Cholecystokinin (26-33), sulfated; CCK Octapeptide; Ceruletide Diethylamine
EINECS	Contact for details

Quality Control

Our Sincalide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, peptide content determination, and identity confirmation via mass spectrometry. We provide Certificates of Analysis (COA) with detailed results for all release specifications, ensuring traceability and compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	5.0% - 12.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.