Description

Pregna-1,4-Diene-3,20-Dione, 17-(Acetyloxy)-21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-, (11β,16β)- is a high-purity synthetic steroid derivative of significant pharmaceutical interest. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) in the synthesis of potent corticosteroid medications. It is primarily required by pharmaceutical R&D laboratories and API manufacturing facilities for the development and production of specialized anti-inflammatory and immunosuppressive drugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of high-potency topical and systemic corticosteroids.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel steroid-based therapeutics.
• Anti-inflammatory Drug Synthesis: Precursor for medications targeting dermatological conditions, arthritis, and autoimmune disorders.
• Biochemical Research: Tool compound for studying glucocorticoid receptor activity and steroid metabolism pathways.
• Veterinary Pharmaceutical Manufacturing: Intermediate in the production of anti-inflammatory treatments for animals.

Basic Information

Item	Details
Product Name	Pregna-1,4-Diene-3,20-Dione, 17-(Acetyloxy)-21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-, (11β,16β)-
CAS No.	25122-45-6
Molecular Formula	C24H28ClFO6
Molecular Weight	466.93 g/mol
Synonyms	9-Fluoro-11β,16β,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-acetate; Flumethasone Pivalate Impurity; Flumethasone related compound; 16β-Methyl-9α-fluoro-1,4-pregnadiene-11β,16β,17,21-tetrol-3,20-dione 21-acetate 16,17-acetonide; (11β,16β)-21-(Acetyloxy)-9-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione; 21-Acetoxy-9-fluoro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione derivative is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications. Certificates of Analysis (COA) with full traceability are provided and can be tailored to support GMP compliance for our partners in the pharmaceutical supply chain.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.