Description

5-Ethyluridine is a modified nucleoside analog of uridine, characterized by an ethyl group substitution at the 5-position of the pyrimidine ring. This structural modification is critical for its role as a key intermediate and building block in the synthesis of novel oligonucleotides and therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral drugs, mRNA-based therapies, and advanced molecular biology research. The compound's specific structure allows for fine-tuning of nucleic acid properties, making it valuable for probing biological mechanisms and creating next-generation biopharmaceuticals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the solid-phase synthesis of modified RNA and DNA strands for research and therapeutic applications.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and repair pathways.
• mRNA Technology: Employed in the research and development of modified mRNA for vaccines and protein replacement therapies.
• Antiviral Drug Development: Investigated as a precursor for prodrugs targeting viral polymerases.
• Labeling and Probes: Can be used to create labeled nucleotides for detection and diagnostic assays.

Basic Information

Product Name	5-Ethyluridine
CAS No.	25110-76-3
Molecular Formula	C11H16N2O6
Molecular Weight	272.25 g/mol
Synonyms	5-Ethyluridine; 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-ethylpyrimidine-2,4-dione; 5-Ethyl-1-β-D-ribofuranosyluracil; Uridine, 5-ethyl-; 5-EtUrd; 5-EU
EINECS	Contact for details

Quality Control

Our 5-Ethyluridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and results. Our quality commitment ensures the material is suitable for demanding applications in pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.