Description

trans-1,4-Bis(2-Isothiocyanatoethyl)Cyclohexane is a high-purity, bifunctional isothiocyanate compound used as a critical cross-linking and derivatization reagent. Its value lies in its ability to form stable thiourea bonds with primary amines, making it essential for creating robust conjugates and modifying biomolecules. This product is primarily needed by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing targeted drug delivery systems, diagnostic assays, and specialty polymers.

Application

• Bioconjugation Reagent: For cross-linking proteins, antibodies, peptides, and other amine-containing biomolecules to create stable immunoconjugates or enzyme complexes.
• Pharmaceutical Intermediate: Used in the synthesis of targeted therapeutics, including antibody-drug conjugates (ADCs) and other biopharmaceuticals.
• Diagnostic Assay Development: Employed to label and immobilize antigens or antibodies on solid supports for ELISA, lateral flow assays, and biosensors.
• Polymer Modification: Serves as a cross-linker or functionalization agent in the production of specialty polymers, hydrogels, and functional coatings.
• Affinity Chromatography: Used to functionalize resins and beads for the purification of specific proteins or other biological molecules.
• Research & Development: A key tool in chemical biology and materials science research for studying molecular interactions and creating novel functionalized materials.

Basic Information

Product Name	trans-1,4-Bis(2-Isothiocyanatoethyl)Cyclohexane
CAS No.	25029-11-2
Molecular Formula	C₁₂H₁₈N₂S₂
Molecular Weight	254.41 g/mol
Synonyms	1,4-Bis(2-isothiocyanatoethyl)cyclohexane (trans); trans-Cyclohexane-1,4-diylbis(ethane-2,1-diyl) diisothiocyanate; 1,4-Bis(isothiocyanatoethyl)cyclohexane; BIC; trans-1,4-Bis(2-isothiocyanatoethyl)cyclohexane; 1,4-Bis(2-isothiocyanatoethyl)cyclohexane, trans-; 1,4-Bis(2-isothiocyanatoethyl)-trans-cyclohexane; 4,4'-Diisothiocyanatodicyclohexylmethane derivative
EINECS	Contact for details

Quality Control

Our trans-1,4-Bis(2-Isothiocyanatoethyl)Cyclohexane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions to prevent degradation. Keep away from incompatible materials such as strong bases, amines, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMF, DMSO, acetone; slightly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.