Description

2,4(1H,3H)-Pyrimidinedione, 5-(2,3,5-Tri-o-Acetyl-β-D-Ribofuranosyl)- is a key acetylated ribonucleoside derivative, serving as a crucial protected intermediate in synthetic organic chemistry. Its primary value lies in enabling the controlled synthesis and modification of nucleoside analogs, where the acetyl groups protect reactive hydroxyl sites during complex reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing antiviral agents, anticancer drugs, and novel nucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a protected precursor in oligonucleotide synthesis and nucleotide chemistry studies.
• Prodrug Development: Serves as an intermediate in creating prodrugs with enhanced bioavailability and targeted delivery.
• Antiviral Agent Synthesis: Key starting material for the preparation of modified ribavirin and related therapeutic nucleosides.
• Labeled Compound Production: Intermediate for synthesizing isotopically labeled (e.g., C13, N15) nucleotides for metabolic tracing.
• Polymerase Substrate Analogs: Used to develop modified substrates for enzymatic studies and diagnostic assays.

Basic Information

Item	Details
Product Name	2,4(1H,3H)-Pyrimidinedione, 5-(2,3,5-Tri-o-Acetyl-β-D-Ribofuranosyl)-
CAS No.	24800-34-8
Molecular Formula	C15H18N2O9
Molecular Weight	370.31 g/mol
Synonyms	5-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)uracil; 2',3',5'-Tri-O-acetyluridine; 1-[(2R,3R,4R,5R)-3,4-Diacetyloxy-5-(acetyloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; Triacetyluridine; Uridine 2',3',5'-triacetate; β-Uridine 2',3',5'-triacetate; NSC 20264
EINECS	Contact for details

Quality Control

Our 2,4(1H,3H)-Pyrimidinedione, 5-(2,3,5-Tri-o-Acetyl-β-D-Ribofuranosyl)- is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research and synthesis applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the exacting standards of pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.