Description

2-Chloro-9-(2,3-o-Isopropylidene-β-D-Ribofuranosyl)Adenine is a key nucleoside analog intermediate, specifically a chlorinated adenosine derivative protected with an isopropylidene group. This compound matters for its critical role in the synthesis of modified nucleosides and nucleotides, which are essential building blocks in antiviral and anticancer research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-purity intermediate to develop novel therapeutic agents and diagnostic probes.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies investigating enzyme mechanisms, nucleic acid metabolism, and the development of polymerase inhibitors.
• Pro-drug Synthesis: Acts as a building block for creating masked or targeted pro-drug versions of active nucleoside agents.
• Antisense Oligonucleotide Development: Incorporated into oligonucleotide sequences to modify their stability, binding affinity, and biological activity.
• Labeled Compound Production: A starting material for synthesizing radiolabeled or fluorescently tagged nucleosides for diagnostic and tracking applications.
• Academic & Industrial R&D: Employed in both university and corporate research settings for exploring new chemical entities in medicinal chemistry.

Basic Information

Item	Details
Product Name	2-Chloro-9-(2,3-o-Isopropylidene-β-D-Ribofuranosyl)Adenine
CAS No.	24639-06-3
Molecular Formula	C16H20ClN5O4
Molecular Weight	381.81 g/mol
Synonyms	2-Chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)adenine; 2-Chloroadenosine isopropylidene acetal; 2-Chloro-9-[2,3-O-(1-methylethylidene)-β-D-ribofuranosyl]-9H-adenine; 2-Cl-isoP-Ado; 2-Chloro-2',3'-O-isopropylideneadenosine; 9-(2,3-O-Isopropylidene-β-D-ribofuranosyl)-2-chloroadenine; 2-Chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)-9H-purin-6-amine
EINECS	Contact for details

Quality Control

Our 2-Chloro-9-(2,3-o-Isopropylidene-β-D-Ribofuranosyl)Adenine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.