Description

Carbonochloridic Acid, 1,1-Dimethylethyl Ester is a versatile tert-butyl chloroformate reagent, a key building block in organic synthesis and pharmaceutical manufacturing. Its primary value lies in its role as a protecting agent for amines and alcohols, facilitating complex multi-step syntheses with high selectivity. This compound is essential for research laboratories and industrial-scale producers in the pharmaceutical, agrochemical, and fine chemical sectors who require reliable, high-purity intermediates.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs), particularly in the production of carbamate-protected amino acids and peptides.
• Amine Protecting Agent: Used to introduce the tert-butoxycarbonyl (Boc) protecting group, which is stable under a wide range of reaction conditions and can be selectively removed.
• Polymer Chemistry: Serves as a monomer or modifying agent in the synthesis of specialized polycarbonates and other functional polymers.
• Agrochemical Synthesis: Employed in the manufacture of herbicides, fungicides, and insecticides where the Boc group is a key structural component.
• Peptide Synthesis: A fundamental reagent in solid-phase and solution-phase peptide synthesis for the temporary protection of amino groups.
• Organic Synthesis Reagent: Utilized in various carbonylation and esterification reactions to construct complex molecular architectures.

Basic Information

Product Name	Carbonochloridic Acid, 1,1-Dimethylethyl Ester
CAS No.	24608-52-4
Molecular Formula	C5H9ClO2
Molecular Weight	136.58 g/mol
Synonyms	tert-Butyl Chloroformate; Boc-Cl; tert-Butoxycarbonyl Chloride; BOC Chloride; t-Butyl Chloroformate; 1,1-Dimethylethyl Chloroformate; Chloroformic Acid tert-Butyl Ester; NSC 106977
EINECS	246-365-6

Quality Control

Our Carbonochloridic Acid, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay by titration and impurity profiling, to ensure it meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to minimize degradation and volatility. Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening and allowed to equilibrate to room temperature before use to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (Titration)	≥ 98.0 %
Water Content (KF)	≤ 0.5 %
Related Impurities (GC/HPLC)	≤ 1.0 % (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.