Description

16β-(Acetyloxy)-14,15β-Epoxy-3β,5-Dihydroxy-19-Oxo-5β-Bufa-20,22-Dienolide CAS NO 24512-60-5 is a high-purity, specialized bufadienolide derivative, a class of compounds known for their potent biological activity. This compound is critical for advanced pharmaceutical research and development, particularly in the study of cardiac glycoside analogs and their mechanisms. It serves as a key intermediate and reference standard for scientists in medicinal chemistry and pharmacology. Target users include R&D laboratories, academic institutions, and fine chemical manufacturers focused on novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthetic pathway for novel cardiac glycosides and other steroidal drugs.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and NMR for quality control and method validation in pharmaceutical analysis.
• Medicinal Chemistry Research: A vital tool for structure-activity relationship (SAR) studies to develop new compounds with targeted biological activity.
• Biochemical Research: Employed in in-vitro and ex-vivo studies to investigate ion channel modulation (e.g., Na+/K+-ATPase inhibition) and related cellular pathways.
• Academic Studies: Used in university and institutional research for exploring the chemistry and pharmacology of bufadienolides.
• Fine Chemical Synthesis: Acts as a starting material or advanced intermediate for the custom synthesis of complex, bioactive steroid derivatives.

Basic Information

Product Name	16β-(Acetyloxy)-14,15β-Epoxy-3β,5-Dihydroxy-19-Oxo-5β-Bufa-20,22-Dienolide
CAS No.	24512-60-5
Molecular Formula	C₂₆H₃₂O₈
Molecular Weight	472.53 g/mol
Synonyms	14,15β-Epoxy-3β,5-dihydroxy-19-oxo-5β-bufa-20,22-dienolide 16-acetate; 16β-Acetoxy-14,15β-epoxy-3β,5-dihydroxy-19-oxo-5β-bufa-20,22-dienolide; 3β,5-Dihydroxy-14β,15β-epoxy-19-oxo-5β-bufa-20,22-dienolide 16β-acetate; Bufadienolide derivative; 19-Oxobufalin 16-acetate 14,15-epoxide; (3β,5β,16β)-14,15-Epoxy-3,5,16-trihydroxy-19-oxobufa-20,22-dienolide 16-acetate
EINECS	Contact for details

Quality Control

Our 16β-(Acetyloxy)-14,15β-Epoxy-3β,5-Dihydroxy-19-Oxo-5β-Bufa-20,22-Dienolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and specific tests for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and in original packaging until use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.