Description

16β-(Acetyloxy)-14,15β-Epoxy-3β-Hydroxy-19-Oxo-5β-Bufa-20,22-Dienolide CAS NO 24512-59-2 is a high-purity, specialized bufadienolide derivative, a class of compounds known for their potent biological activity. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the study of cardiac glycoside analogs and their mechanisms. It serves as a critical intermediate or reference standard for researchers and manufacturers in the life sciences sector requiring precise, well-characterized molecules for drug discovery and biochemical studies.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic building block for the development of novel therapeutic agents, particularly in cardiology and oncology research.
• Reference Standard: Used as a high-purity analytical standard in quality control (QC) and research laboratories for method development and compound identification via HPLC, LC-MS, or NMR.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate the biological activity, structure-activity relationships (SAR), and pharmacokinetics of bufadienolide compounds.
• Active Pharmaceutical Ingredient (API) Development: Acts as a precursor or intermediate in the synthesis pathway for potential new Active Pharmaceutical Ingredients (APIs) targeting specific cellular pathways.
• Academic Research: Utilized by universities and research institutes for fundamental studies in natural product chemistry, medicinal chemistry, and pharmacology.

Basic Information

Product Name	16β-(Acetyloxy)-14,15β-Epoxy-3β-Hydroxy-19-Oxo-5β-Bufa-20,22-Dienolide
CAS No.	24512-59-2
Molecular Formula	C₂₆H₃₄O₇
Molecular Weight	458.55 g/mol
Synonyms	14β,15β-Epoxy-3β,16β-dihydroxy-19-oxobufa-20,22-dienolide 16-acetate; 16β-Acetoxy-14β,15β-epoxy-3β-hydroxy-19-oxo-5β-bufa-20,22-dienolide; Bufadienolide derivative; 3β,16β-Dihydroxy-14β,15β-epoxy-19-oxobufa-20,22-dienolide 16-acetate; 19-Oxobufalin 16-acetate 14,15-epoxide; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 16β-(Acetyloxy)-14,15β-Epoxy-3β-Hydroxy-19-Oxo-5β-Bufa-20,22-Dienolide is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.