Description

17-α-Hydroxy-16-α-Methyl-3,20-Dioxopregna- 1,4-Dien-21-Yl Acetate is a high-purity steroid derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical synthetic intermediate for the development of potent glucocorticoids and other specialized therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs) and novel steroid-based drugs.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid APIs, such as dexamethasone and related analogs.
• Research & Development: Used in medicinal chemistry research for the design, development, and structure-activity relationship (SAR) studies of new anti-inflammatory and immunosuppressive agents.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, complex steroid molecules.
• Reference Standard: Serves as a certified reference material (CRM) or analytical standard for quality control and regulatory testing in pharmaceutical laboratories.

Basic Information

Product Name	17-α-Hydroxy-16-α-Methyl-3,20-Dioxopregna- 1,4-Dien-21-Yl Acetate
CAS No.	24510-54-1
Molecular Formula	C24H30O5
Molecular Weight	398.50 g/mol
Synonyms	9α-Fluoro-11β,17α,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate; 9α-Fluoro-16α-methylprednisolone 21-acetate; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate; Dexamethasone 21-acetate precursor; 16α-Methyl-9α-fluoroprednisolone 21-acetate; δ1-9α-Fluoro-16α-methylhydrocortisone 21-acetate
EINECS	Contact for details

Quality Control

Our 17-α-Hydroxy-16-α-Methyl-3,20-Dioxopregna- 1,4-Dien-21-Yl Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.