Description

2-Iodoestradiol is a halogenated derivative of the natural hormone estradiol, specifically iodinated at the 2-position of the steroid nucleus. This structural modification makes it a valuable intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel steroid-based compounds, hormone receptor studies, and the development of targeted radiopharmaceuticals. The compound's defined structure provides a critical building block for probing biochemical pathways and creating specialized diagnostic or therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel steroid-based therapeutics and diagnostic agents.
• Biochemical Research: Used as a reference standard and tool compound in studies of estrogen receptor binding, function, and signaling pathways.
• Radiopharmaceutical Development: Serves as a precursor for the synthesis of iodine-123 or iodine-131 labeled compounds for diagnostic imaging or targeted radiotherapy research.
• Academic & Industrial R&D: Employed in organic synthesis laboratories for method development and the creation of specialized chemical libraries.
• Reference Material: Used to calibrate analytical equipment (HPLC, GC-MS) and validate testing methods for quality control in steroid analysis.

Basic Information

Product Name	2-Iodoestradiol
CAS No.	24381-12-2
Molecular Formula	C18H23IO2
Molecular Weight	422.28 g/mol
Synonyms	2-Iodoestra-1,3,5(10)-triene-3,17β-diol; Estra-1,3,5(10)-triene-3,17-diol, 2-iodo-; 2-Iodo-17β-estradiol; 2-Iodo-E2; 2-Iodoestradiol-17β
EINECS	Contact for details

Quality Control

Our 2-Iodoestradiol is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under inert atmosphere at lower temperatures (e.g., -20°C) to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.