Description

Terameprocol is a synthetic tetra-O-methyl derivative of nordihydroguaiaretic acid (NDGA) with significant biological activity. This compound is valued for its potent and specific inhibition of the transcription factor Sp1, which plays a crucial role in regulating genes involved in cell growth and survival. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors. Terameprocol CAS NO 24150-24-1 represents a key intermediate and active ingredient for advanced therapeutic development.

Application

• Pharmaceutical Research & Development: As a lead compound or reference standard in oncology research, particularly for investigating Sp1-mediated pathways in cancer cell proliferation and apoptosis.
• Preclinical Studies: Used in in vitro and in vivo models to evaluate antitumor, antiviral, and anti-inflammatory efficacy.
• Biochemical Assay Development: Serves as a specific inhibitor in assays designed to study transcription factor activity and gene expression regulation.
• API Intermediate: Acts as a critical synthetic intermediate in the production pathway for more complex therapeutic agents targeting specific cellular mechanisms.
• Academic Research: Employed in university and institutional labs for fundamental studies in molecular biology, biochemistry, and medicinal chemistry.

Basic Information

Product Name	Terameprocol
CAS No.	24150-24-1
Molecular Formula	C23H30O4
Molecular Weight	370.48 g/mol
Synonyms	EM-1421; Tetra-O-methyl nordihydroguaiaretic acid; NSC 656158; Tetramethoxy NDGA; 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-bis(methoxymethoxy)benzene]; Meso-3,4-bis(3,4-bis(methoxymethoxy)phenyl)hexane
EINECS	Contact for details

Quality Control

Our Terameprocol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and NMR. We provide full traceability and support regulatory submissions. Certificates of Analysis (COA) documenting all test results are available upon request to ensure compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.