Description

2'-O-Methylguanosine 5'-Monophosphate is a chemically modified nucleotide monophosphate, specifically a guanosine derivative with a methyl group at the 2'-hydroxyl position of the ribose sugar. This modification is critical for enhancing the stability and altering the biological activity of oligonucleotides, making it a valuable building block for advanced research and therapeutic development. It is primarily utilized by biotechnology and pharmaceutical companies engaged in nucleic acid chemistry, antisense technology, and the synthesis of modified RNA analogs.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key phosphoramidite precursor for creating stable, nuclease-resistant therapeutic oligonucleotides.
• siRNA and miRNA Research: Used to introduce 2'-O-methyl modifications into RNA strands to improve pharmacokinetic properties and reduce off-target effects.
• Structural Biology Studies: Employed to probe RNA structure, function, and protein-RNA interactions due to its altered sugar conformation.
• Diagnostic Probe Development: Incorporated into nucleic acid probes to enhance stability and specificity in diagnostic assays.
• Pharmaceutical Intermediates: Serves as a high-purity intermediate in the development of nucleotide-based drugs.
• Biochemical Research: A substrate for enzymatic studies involving polymerases and nucleotidyltransferases to understand modification impacts.

Basic Information

Product Name	2'-O-Methylguanosine 5'-Monophosphate
CAS No.	24121-01-5
Molecular Formula	C11H16N5O8P
Molecular Weight	377.25 g/mol
Synonyms	2'-O-Methyl-GMP; 2'-O-Methylguanosine monophosphate; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-6-amino-1H-purin-2-one 5'-(dihydrogen phosphate); 2'-O-Methyl-5'-GMP; Guanosine, 2'-O-methyl-, 5'-(dihydrogen phosphate); 2'-Me-GMP; 2'-OMe-Guanosine-5'-monophosphate
EINECS	Contact for details

Quality Control

Our 2'-O-Methylguanosine 5'-Monophosphate is manufactured under strict quality systems suitable for research and pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets exacting specifications. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvent, and related substance profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.