Description

5'-Adenylic Acid, 2'-o-Methyl- is a chemically modified nucleotide analog where a methyl group is introduced at the 2'-hydroxyl position of the ribose sugar. This modification is crucial for enhancing the stability and bioavailability of oligonucleotides, making it a vital building block in advanced therapeutic and diagnostic research. It is primarily utilized by biotechnology and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA, and other RNA-based therapeutics where nuclease resistance is a key requirement.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A critical phosphoramidite monomer for constructing oligonucleotides with improved metabolic stability.
• Small Interfering RNA (siRNA) Development: Used to introduce 2'-O-methyl modifications, enhancing siRNA duplex stability and reducing off-target effects.
• Therapeutic Aptamer Research: Serves as a modified nucleotide in the selection and synthesis of nuclease-resistant aptamers for targeted drug delivery.
• Diagnostic Probe Manufacturing: Incorporated into fluorescent probes and molecular beacons to increase their longevity in complex biological samples.
• Biochemical Research: A valuable tool for studying RNA structure, function, and RNA-protein interactions.
• Pharmaceutical Intermediates: Acts as a key intermediate in the production of novel nucleoside-based antiviral and anticancer agents.

Basic Information

Product Name	5'-Adenylic Acid, 2'-o-Methyl-
CAS No.	24121-00-4
Molecular Formula	C11H15N5O6P
Molecular Weight	344.24 g/mol
Synonyms	2'-O-Methyladenosine 5'-monophosphate; 2'-O-Methyl-AMP; 2'-O-Methyladenylic acid; Adenosine 2'-methylphosphate; 2'-Methoxyadenosine 5'-phosphate; 2'-OMe-AMP; 2'-O-Methyladenosine monophosphate; 5'-Adenylic acid 2'-methyl ether
EINECS	Contact for details

Quality Control

Our 5'-Adenylic Acid, 2'-o-Methyl- is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality assurance protocols are designed to meet the stringent requirements of oligonucleotide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.