Description

8-Methylguanine is a modified purine nucleobase that serves as a critical biochemical marker and research reagent. Its primary significance lies in its role as a biomarker for DNA damage and its utility in studying DNA repair mechanisms and epigenetic processes. This compound is essential for researchers and manufacturers in the fields of pharmaceutical development, molecular biology, and diagnostic assay production, where precise biochemical tools are required.

Application

• Biochemical Research: Used as a standard and reagent in studies of DNA alkylation damage, repair pathways, and mutagenesis.
• Diagnostic Development: Serves as a key component in the development of assays for detecting oxidative stress and DNA damage biomarkers.
• Pharmaceutical R&D: Employed in the research of novel chemotherapeutic agents and compounds targeting DNA repair enzymes.
• Epigenetics Studies: Utilized in investigations concerning DNA methylation and related epigenetic modifications.
• Reference Standard: Acts as a high-purity analytical standard for chromatography (HPLC, LC-MS) and spectroscopy in quality control laboratories.
• Enzyme Substrate: Applied in enzymatic studies, particularly for methyltransferases and glycosylases involved in base excision repair.

Basic Information

Product Name	8-Methylguanine
CAS No.	23662-75-1
Molecular Formula	C6H7N5O
Molecular Weight	165.15 g/mol
Synonyms	8-Methylguanine; 2-Amino-8-methyl-1,7-dihydro-6H-purin-6-one; 8-Methyl-2-aminohypoxanthine; Guanin-8-ylmethane; 8-MG; N8-Methylguanine; 8-Methyl-Guanine
EINECS	Contact for details

Quality Control

Our 8-Methylguanine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.