Description

8-Bromoadenosine 5'-Diphosphate is a chemically modified nucleotide analog where a bromine atom is substituted at the 8-position of the adenine base. This modification is critical for its role as a potent and selective antagonist of the P2Y1 purinergic receptor, a key target in platelet aggregation and cardiovascular research. It serves as an essential biochemical tool for researchers and pharmaceutical developers in life sciences, particularly for studying nucleotide signaling pathways, enzyme inhibition, and as a precursor for synthesizing more complex nucleotide derivatives.

Application

• P2Y1 Receptor Research: Primary use as a selective antagonist for studying P2Y1 receptor-mediated signaling in platelets and other cell types.
• Cardiovascular & Thrombosis Studies: Investigation of platelet aggregation mechanisms and development of novel anti-thrombotic agents.
• Enzymology: Substrate or inhibitor for studies involving nucleotide-metabolizing enzymes like kinases, phosphatases, and adenylate cyclases.
• Biochemical Probe Development: Used as a building block for synthesizing affinity labels, fluorescent probes, or photoaffinity labels for protein interaction studies.
• Cell Signaling Pathway Analysis: Tool for dissecting purinergic signaling cascades in immunology, neurology, and oncology research.
• Pharmaceutical Intermediate: Key starting material in the synthesis of novel therapeutic nucleotide analogs.

Basic Information

Product Name	8-Bromoadenosine 5'-Diphosphate
CAS No.	23600-16-0
Molecular Formula	C10H14BrN5O10P2
Molecular Weight	522.10 g/mol
Synonyms	8-Br-ADP; 8-Bromo-ADP; 8-Bromoadenosine diphosphate; Adenosine 5'-(trihydrogen diphosphate), 8-bromo-; 8-Bromoadenosine-5'-diphosphate; P1-(8-Bromoadenosine-5')-P2-(adenosine-5') diphosphate (common misnomer); 8-Br-Adenosine-5'-diphosphate; 8-Bromo-5'-ADP
EINECS	Contact for details

Quality Control

Our 8-Bromoadenosine 5'-Diphosphate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles. We support compliance with relevant research and development guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by UV)
Water Content (KF)	≤ 5%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.