Description

8-Bromoadenosine 5'-Monophosphate is a modified nucleotide monophosphate where a bromine atom is introduced at the 8-position of the adenine base. This modification is crucial for its role as a potent and selective inhibitor of cyclic nucleotide phosphodiesterases, making it a valuable biochemical tool for studying cellular signaling pathways. It is primarily utilized by researchers and manufacturers in the life sciences sector for enzyme kinetics studies, drug discovery, and the development of diagnostic assays.

Application

• Biochemical Research: As a key inhibitor for studying cyclic AMP (cAMP) and cyclic GMP (cGMP) signaling cascades in cell biology and pharmacology.
• Enzyme Assay Development: Used in the design and validation of high-throughput screening assays for phosphodiesterase (PDE) activity.
• Pharmaceutical R&D: Serves as a reference standard and a lead compound scaffold in the discovery of novel PDE-targeted therapeutics for conditions like cardiovascular disease and inflammation.
• Diagnostic Reagents: A component in specialized diagnostic kits for measuring phosphodiesterase levels or activity in clinical research samples.
• Academic Studies: Employed in university and institutional laboratories for fundamental research on nucleotide metabolism and second messenger systems.

Basic Information

Product Name	8-Bromoadenosine 5'-Monophosphate
CAS No.	23567-96-6
Molecular Formula	C10H13BrN5O7P
Molecular Weight	426.12 g/mol
Synonyms	8-Br-AMP; 8-Bromo-AMP; 8-Bromoadenosine monophosphate; 8-Bromoadenosine 5'-(dihydrogen phosphate); 8-Bromo-5'-adenylic acid; Adenosine, 8-bromo-, 5'-(dihydrogen phosphate); 8-Bromoadenosine 5'-phosphate
EINECS	Contact for details

Quality Control

Our 8-Bromoadenosine 5'-Monophosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.