Description

4-Methyltrityl Chloride is a versatile and highly reactive organochlorine compound used as a key protecting group reagent in organic synthesis. Its primary value lies in its selective reactivity, which allows for the efficient protection of hydroxyl groups, particularly in the synthesis of complex molecules like nucleotides and pharmaceuticals. This compound is essential for research chemists and process development scientists working in pharmaceutical R&D, agrochemical production, and fine chemical manufacturing. The reliable quality and consistent performance of our 4-Methyltrityl Chloride ensure reproducible results in critical synthetic pathways.

Application

• Nucleotide and Oligonucleotide Synthesis: As a critical protecting group reagent for the 5'-hydroxyl function in phosphoramidite chemistry during automated DNA/RNA synthesis.
• Pharmaceutical Intermediates: Used in the multi-step synthesis of active pharmaceutical ingredients (APIs) where selective protection of alcohol groups is required.
• Carbohydrate Chemistry: Employed for the protection of specific hydroxyl groups in the synthesis of complex sugars and glycosides.
• Peptide Synthesis: Can be utilized for the temporary protection of serine, threonine, or tyrosine side chains in solid-phase peptide synthesis (SPPS).
• Material Science Research: Serves as a building block or modifying agent in the development of specialty polymers and functionalized surfaces.
• Agrochemical Synthesis: Used in the production of certain herbicides and plant growth regulators that require protected alcohol intermediates.

Basic Information

Product Name	4-Methyltrityl Chloride
CAS No.	23429-44-9
Molecular Formula	C20H17Cl
Molecular Weight	292.80 g/mol
Synonyms	MMTr-Cl; 4-Monomethoxytrityl Chloride; (4-Methoxyphenyl)diphenylmethyl Chloride; α-Chloro-4-methoxytriphenylmethane; p-Methoxytrityl Chloride; 4-Methoxytrityl Chloride; Chloro(4-methoxyphenyl)diphenylmethane; 4-Methyltritylchlorid
EINECS	Contact for details

Quality Control

Our 4-Methyltrityl Chloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. Each lot is tested against rigorous in-house specifications, with a focus on parameters critical for protecting group efficiency, such as assay and water content. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.