Description

5'-Tosyladenosine-2',3'-o-Phenylboronate is a key nucleoside derivative and a protected intermediate used in synthetic organic chemistry. This compound is critical for the controlled synthesis of modified nucleotides and oligonucleotides, enabling precise chemical modifications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries for the development of active pharmaceutical ingredients (APIs), prodrugs, and novel molecular probes.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase or solution-phase synthesis of modified DNA/RNA strands.
• Prodrug Development: Used to create masked or targeted prodrug forms of nucleoside analogs to improve bioavailability and reduce side effects.
• Bioconjugation & Labeling: Facilitates the site-specific attachment of reporter molecules, fluorophores, or targeting ligands to nucleosides.
• Chemical Biology Research: Enables the study of nucleic acid structure, function, and interactions through the introduction of specific chemical handles.
• Agrochemical Research: Employed in the discovery and development of novel nucleoside-based pesticides and plant growth regulators.

Basic Information

Product Name	5'-Tosyladenosine-2',3'-o-Phenylboronate
CAS No.	23312-76-7
Molecular Formula	C23H24BN5O7S
Molecular Weight	501.34 g/mol
Synonyms	2',3'-O-(Phenylboronate)-5'-O-tosyladenosine; Adenosine, 5'-(4-methylbenzenesulfonate), 2',3'-(phenylboronate); 5'-O-(p-Toluenesulfonyl)adenosine 2',3'-phenylboronate; N6-Benzoyl-5'-O-tosyladenosine 2',3'-cyclic phenylboronate (related protected form); Ts-Ado-PhB; TAPB; Nucleoside tosylate boronate ester
EINECS	Contact for details

Quality Control

Our 5'-Tosyladenosine-2',3'-o-Phenylboronate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.