Description

Guanabenz Acetate CAS NO 23256-50-0 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) with significant pharmacological activity. This compound is valued for its role as a precursor in the synthesis of critical therapeutic agents, particularly within the central nervous system. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in drug discovery and development.

Application

• Pharmaceutical API Synthesis: A key intermediate in the production of Guanabenz, an α-2 adrenergic agonist used in antihypertensive medications.
• Neurological Research: Employed in preclinical and clinical studies investigating adrenergic receptor mechanisms and related neurological pathways.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research: Used in studies exploring cellular stress responses, including research on the integrated stress response (ISR) pathway.
• Formulation Development: Utilized in the development and testing of various dosage forms, including tablets and injectables.

Basic Information

Product Name	Guanabenz Acetate
CAS No.	23256-50-0
Molecular Formula	C10H10Cl2N4 · C2H4O2
Molecular Weight	291.14 g/mol (Free base: 231.11 g/mol)
Synonyms	Guanabenz acetate salt; 2,6-Dichlorobenzylidene aminoguanidine acetate; (2,6-Dichlorobenzylideneamino)guanidine acetate; WY-8678 acetate; Wy-8678 acetate salt; Benzylideneaminoguanidine acetate derivative; Guanabenz acetic acid salt
EINECS	Contact for details

Quality Control

Our Guanabenz Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, related substances, residual solvents, and heavy metals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.