Description

2',3',5'-Tri-o-Acetyl-8-Fluoro Adenosine is a key fluorinated nucleoside derivative, serving as a crucial protected intermediate in advanced organic synthesis. Its primary value lies in enabling the precise construction of modified oligonucleotides and nucleoside analogs, where the acetyl groups provide essential protection for subsequent selective reactions. This compound is particularly vital for researchers and manufacturers in the pharmaceutical and biotechnology sectors, especially those developing novel antiviral agents, anticancer therapeutics, and diagnostic probes.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel fluorinated nucleoside-based drugs, including potential antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a protected monomer in solid-phase and solution-phase synthesis of modified DNA/RNA strands for research and therapeutic applications (e.g., antisense oligonucleotides, siRNA).
• Biochemical Research: Serves as a precursor for studying enzyme mechanisms (e.g., kinase and polymerase activity) involving fluorinated adenosine analogs.
• Probe Development: Utilized in creating labeled nucleosides for diagnostic assays and imaging techniques due to the presence of the fluorine atom.
• Process Chemistry: Employed in scaling up the production of high-value, complex nucleoside targets under controlled GMP-like conditions.

Basic Information

Product Name	2',3',5'-Tri-o-Acetyl-8-Fluoro Adenosine
CAS No.	23205-66-5
Molecular Formula	C17H19FN6O7
Molecular Weight	438.37 g/mol
Synonyms	8-Fluoro-2',3',5'-tri-O-acetyladenosine; 8-Fluoroadenosine 2',3',5'-triacetate; Adenosine, 8-fluoro-2',3',5'-triacetate; 8-Fluoro-2',3',5'-tri-O-acetyl-adenosine; 8-Fluoroadenosine triacetate; N6-(8-Fluoroadenosine-2',3',5'-triyl triacetate); 23205-66-5
EINECS	Contact for details

Quality Control

Our 2',3',5'-Tri-o-Acetyl-8-Fluoro Adenosine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.