Description

3-Deazauridine is a synthetic pyrimidine nucleoside analog with significant biochemical research applications. This compound is valued for its role as a potent inhibitor of cytidine triphosphate synthetase, making it a critical tool for studying nucleotide metabolism and enzyme function. It is primarily utilized by research institutions and pharmaceutical companies engaged in biochemical pathway analysis, antiviral research, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a specific inhibitor to study the enzymatic activity and regulation of cytidine triphosphate (CTP) synthetase in metabolic pathways.
• Antiviral Studies: Investigated for its potential to interfere with viral replication by disrupting the synthesis of essential pyrimidine nucleotides.
• Cell Biology & Oncology Research: Employed in studies exploring cell proliferation, differentiation, and apoptosis, particularly in cancer cell lines where nucleotide metabolism is dysregulated.
• Enzyme Kinetics & Mechanism: Serves as a valuable probe for understanding the binding sites and catalytic mechanisms of nucleotide-processing enzymes.
• Reference Standard: Used as a high-purity analytical standard in pharmaceutical quality control and method development for related compounds.

Basic Information

Product Name	3-Deazauridine
CAS No.	23205-42-7
Molecular Formula	C9H13N3O5
Molecular Weight	243.22 g/mol
Synonyms	3-Deazauridine; 1-(β-D-Ribofuranosyl)-1,4-dihydro-2,4-dioxopyrimidine; 4-Hydroxy-1-(β-D-ribofuranosyl)-2(1H)-pyrimidinone; 1-(β-D-Ribofuranosyl)-4-pyrimidinol; NSC 126849; 3-DU; 3-Deaza-Uridine; 1-(β-D-Ribofuranosyl)-1,2-dihydro-2,4(3H,5H)-pyrimidinedione
EINECS	Contact for details

Quality Control

Our 3-Deazauridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.