Description

2-Chloro-5-(Trifluoromethyl)Phenyl Isothiocyanate is a versatile and highly reactive organic intermediate characterized by its phenyl isothiocyanate core functionalized with chloro and trifluoromethyl substituents. This molecular architecture makes it a critical building block for synthesizing advanced heterocyclic compounds and functional materials. It is primarily sought after by research institutions and industrial manufacturers in the agrochemical and pharmaceutical sectors for developing novel active ingredients and specialty chemicals.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the trifluoromethyl and isothiocyanate groups.
• Pharmaceutical Research: Used in medicinal chemistry for constructing pharmacologically active scaffolds, particularly in the development of potential enzyme inhibitors and receptor ligands.
• Ligand Synthesis: Serves as a starting material for preparing specialized ligands used in catalysis and material science applications.
• Dyestuff and Pigment Manufacturing: Employed in the production of specialized dyes and pigments where the chloro and trifluoromethyl groups impart specific color and stability properties.
• Polymer Modification: Acts as a reactive monomer or cross-linking agent to introduce specific functional groups into polymer chains, enhancing material properties.
• Chemical Synthesis Reagent: Utilized in organic synthesis laboratories for the preparation of thiourea derivatives and other sulfur-containing compounds via nucleophilic addition reactions.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Phenyl Isothiocyanate
CAS No.	23165-49-3
Molecular Formula	C8H3ClF3NS
Molecular Weight	237.63 g/mol
Synonyms	1-Chloro-4-Isothiocyanato-2-(Trifluoromethyl)Benzene; 2-Chloro-α,α,α-Trifluoro-p-Tolyl Isothiocyanate; 2-Chloro-α,α,α-Trifluoro-p-Phenylene Isothiocyanate; 2-Chloro-5-Trifluoromethylphenyl Isothiocyanate; Isothiocyanic Acid, 2-Chloro-5-(Trifluoromethyl)Phenyl Ester; 2-Chloro-5-(Trifluoromethyl)Benzenisothiocyanate
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Phenyl Isothiocyanate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support custom synthesis and can tailor purity grades to meet specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.